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Metrorrhagia refers to uterine bleeding appearing at completely irregular
intervals, the amount of flow being profuse during a short period or scanty over
a prolonged period.
Etiology and Pathogenesis
The dysfunction of the Chong and Ren meridians failing to control menstrual flow
is considered the mechanism of metrorrhagia. This may result from blood-heat,
spleen deficiency, kidney deficiency, stagnation of liver-qi, blood stasis or
dampness-heat.
Diagnosis and Differential Diagnosis
A. Diagnostic evidence:
(a) uterine bleeding not occurring at regular cycles;
(b) abrupt and profuse bleeding or prolonged and dripping bleeding.
B. Differential diagnosis:
Metrorrhagia may be distinguished from (a) metrorrhagia, (b) prolonged menstrual
period, and (c) uterine bleeding not occurring in the menstrual period.
Syndrome Differentiation and Treatment
Whether the disorder is attributed to cold or heat, asthenia or sthenia
syndrome, should be based on the quality, color and quantity of uterine
bleeding. Sudden occurrence of profuse uterine bleeding at irregular intervals
followed by dripping of light-colored and thin blood suggests an
asthenia-syndrome. A large amount of bright red or purplish red and viscous
discharge indicates a heat-syndrome. A dark purplish and odorous discharge
containing blood clots reveals a heat-dampness syndrome. Bleeding with acute
onset usually suggests a qi-deficiency syndrome, while a dripping flow over a
long period of time indicates a blood-stasis syndrome. A dull-colored and thin
flow indicates an asthenia-cold syndrome. A chronic case usually signifies
deficiency and stagnation of qi and blood.
In addition, the imbalance between kidney-yin and yang and the dysfunction of
liver and spleen should be noticed such as insufficiency of kidney-qi and
deficiency of the Chong and Ren meridians during puberty, impairment of the
Chong and Ren meridians in a woman of childbearing age and consumption of the
liver and kidneys and weakness of spleen-qi during menopause.
Generally speaking, secondary symptoms appear during the bleeding, and the
manifestation of the primary disease may appear after the bleeding is reduced or
stopped. Accordingly, the following therapies may be adopted flexibly according
to the therapeutic principle of "relieving the secondary symptoms in an acute
case, and dealing with the primary cause in a chronic case."
A. Hemostatic therapy: It should be employed first during a profuse bleeding,
otherwise collapse-syndrome will develop. However, the drugs applied should vary
with different syndromes (cold or heat, asthenia or sthenia).
B. Causative treatment: The therapy should aim at the cause, and indiscriminate
use of cold-natured drugs of warm-natured tonics is harmful.
C. Restoration therapy: This therapy restores the bodily functions and the
health of the patient. The therapy of tonifying the kidneys and invigorating the
spleen is applied successively according to which organ is chiefly affected.
The treatment of individual cases should be based on the following
classifications:
A. Blood-heat syndrome
(a) Sthenia-heat syndrome
Manifestations: Profuse or dripping bleeding with dark red or dull purplish and
viscous discharge containing clots, flushed face, dryness of mouth,
restlessness, thirst with desire for cold drink, red tongue with yellow coating
and smooth and rapid pulse.
Therapeutic principles: Clear away heat, cool the blood, and stop bleeding.
Prescription: The Modified Decoction for Clearing Away Heat and Checking Uterine
Bleeding
Cortex Lycii Radicis 10 g
Radix Rehmanniae 15 g
Plastrum Testudinis 15 g
Pulvis Concha Ostreae (decocted) 30 g
Colla Corii Asini 10 g
Fructus Gardeniae 10 g
Radix Sanguisorbae 15 g
Radix Scutellariae 10 g
Nodus Nelumbinis Rhizomatis 15 g
Vagina Trachycarpi Carbonisatus 15 g
Radix Glycyrrhizae 6 g
Radix Ophiopogonis 10 g
Remarks: For cases accompanied by stagnation of heat in the liver meridian
manifested as distending pain over the lower abdomen and hypochondria,
irritability and wiry pulse, add Radix Bupleuri (10 g) to disperse the stagnated
liver-qi, Spica Prunellae (10 g) to clear away liver-heat and Herba Leonuri (15
g) to eliminate blood stasis. For cases with fatigue and listlessness due to
exhaustion of qi and yin by sthenic heat, add Radix Adenophorae Strictae (15 g)
to benefit qi and nourish yin.
(b) Asthenia-heat syndrome
Manifestations: Continuous dripping or sudden profuse discharge of bright red
and viscous blood, dizziness, tinnitus, restlessness, hectic fever, insomnia,
dreaminess, yellow urine or constipation, red tongue with yellow coating and
thready and rapid pulse.
Therapeutic principles: Nourish yin, clear away heat, arrest bleeding, and
regulate menstruation.
Prescription: The Modified Decoction for Promoting Yin
Radix Ophiopogonis 10 g
Fructus Schisandrae 10 g
Colla Corii Asini 10 g
Radix Rehmanniae 15 g
Radix Rehmanniae Praeparata 15 g
Radix Paeoniae Alba 15 g
Rhizoma Dioscoreae 15 g
Radix Dipsaci 10 g
Radix Scutellariae 10 g
Cortex Phellodendri 10 g
Radix Glycyrrhizae 6 g
B. Spleen-deficiency syndrome
Manifestations: Profuse or dripping bleeding with reddish and thin discharge,
pale complexion, puffy face, shortness of breath, fatigue, cold limbs, poor
appetite, abdominal distention, loose stool, reddish and corpulent tongue with
thin and moist or greasy coating and weak pulse.
Therapeutic principles: Tonify qi, stop bleeding, nourish blood, and regulate
menstruation.
Prescription: The Decoction of Strengthening the Root for Relieving Menorrhagia
Radix Codonopsis Pilosulae 15 g
Radix Astragali Praeparata 15 g
Rhizoma Atractylodis Macrocephalae 15 g
Radix Rehmanniae Praeparata 15 g
Radix Angelicae Sinensis 10 g
Rhizoma Zingiberis Praeparata 6 g
Remarks: For cases with profuse bleeding, add Herba Agrimoniae (15 g) and Galla
Chinensis (10 g), and omit Angelicae Sinensis. For cases with prolonged dripping
bleeding, add Pollen Typhae (fried, 10 g) and Os Sepiellae seu Sepiae (15 g).
For cases with insomnia and palpitations, add Semen Ziziphi Spinosae (fried, 15
g), Fructus Schisandrae (15 g) and Caulis Polygoni Multiflori (15 g).
C. Kidney-deficiency syndrome
(a) Kidney-yin deficiency syndrome
Manifestations: Dripping bleeding with small amount of bright red discharge,
dizziness, tinnitus, feverish sensation over the chest, palms and soles,
insomnia, night sweating, soreness and weakness of loins and legs or lumbago and
heel pain, red tongue with little coating and thready, rapid and weak pulse.
Therapeutic principles: Invigorate kidneys, tonify yin, supplement essence, and
arrest bleeding.
Prescription: The Modified Bolus of Six Drugs Containing Rehmanniae Praeparata
Radix Rehmanniae Praeparata 15 g
Rhizoma Dioscoreae 15 g
Poria 10 g
Cortex Moutan Radicis 10 g
Rhizoma Alismatis 10 g
Fructus Ligustri Lucidi 12 g
Herba Ecliptae 20 g
Fructus Lycii 10 g
Colla Corii Asini 10 g
Plastrum Testudinis 15 g
Herba Agrimoniae 15 g
(b) Kidney-yang deficiency syndrome
Manifestations: Irregular menstrual cycles, sudden profuse or dripping bleeding
with reddish or dull and thin discharge, dimmish complexion, lower abdominal
bearing-down sensation, soreness and weakness of lumbus and legs, pale tongue
with thin, white coating and deep and thready pulse.
Therapeutic principles: Warm the kidneys, strengthen the Chong meridian,
regulate menstruation, and stop bleeding.
Prescription: The Modified Yougui Bolus
Radix Rehmanniae Praeparata 15 g
Rhizoma Dioscoreae 15 g
Fructus Corni 10 g
Fructus Lycii 15 g
Semen Cuscutae 15 g
Colla Cornus Cervi 15 g
Cortex Eucommiae 15 g
Radix Aconiti Lateralis Praeparata 6 g
Radix Astragali 15 g
Halloysitum Rubrum 15 g
Fructus Psoraleae 15 g
Fructus Rubi 15 g
Remarks: For young women with insufficiency of kidney-qi, add Placenta Hominis
(10 g) and Herba Epimedii (10 g) to enhance the effects of invigorating the
kidneys and benefiting the Chong meridian. For cases accompanied by deficiency
of spleen-yang manifested as edema, poor appetite and cold extremities, add
Rhizoma Atractylodis Macrocephalae (fried, 15 g), Fructus Amomi (6 g) and
Rhizoma Zingiberis Praeparata (6 g) to benefit the spleen and warm the
middle-jiao.
(c) Liver-qi stagnation and blood-heat syndrome
Manifestations: Irregular menstrual cycles, dripping or profuse discharge of red
and viscous blood containing clots, distending pain over the lower abdomen,
hypochondrium and breasts, irritability, red tongue with yellow coating and wiry
and rapid pulse.
Therapeutic principles: Calm the liver, disperse the stagnated liver-qi,
regulate the Chong meridian, and stop bleeding.
Prescription: The Decoction for Calming the Liver, Alleviating Mental Depression
and Stopping Bleeding
Radix Paeoniae Alba 10 g
Rhizoma Atractylodis Macrocephalae 10 g
Radix Angelicae Sinensis 10 g
Cortex Moutan Radicis 10 g
Radix Rehmanniae 15 g
Radix Bupleuri 10 g
Herba Schizonepetae Carbonisatus 10 g
Radix Notoginseng 6 g
Radix Glycyrrhizae 6 g
Remarks: For cases with profuse bleeding, add Radix Sanguisorbae (15 g) and
Rhizoma Dryopteris Crassirhizomae (15 g) to clear away heat and stop bleeding.
For cases with hypofunction of spleen manifested as menorrhagia, shortness of
breath and poor appetite, add Radix Astragali (15 g), Rhizoma Atractylodis
Macrocephalae (10 g) and Rhizoma Dioscoreae to benefit qi and strengthen the
spleen.
(d) Blood-stasis syndrome
Manifestations: Dripping or sudden profuse bleeding with purple and clotted
discharge, lower abdominal pain and tenderness which can be relieved by
discharge of clots, petechiae on the tongue margin and deep and unsmooth pulse.
Therapeutic principles: Activate blood circulation, eliminate blood stasis,
regulate the Chong meridian, and stop bleeding.
Prescription: The Decoction of Persicae and Carthami in Four Drugs
Semen Persicae 10 g
Radix Angelicae Sinensis 12 g
Radix Rehmanniae Praeparata 15 g
Rhizoma Chuanxiong 10 g
Radix Paeoniae Alba 15 g
Flos Carthami 10 g
Remarks: For cases with cold pain over the lower abdomen due to stagnation of
cold and blood, add Folium Artemisiae Argyi Carbonisatus (6 g) and Rhizoma
Zingiberis Carbonisatus (6 g) to warm meridians and arrest bleeding. For cases
with profuse bleeding, omit Angelicae Sinensis and Persicae and add Radix
Notoginseng (6 g) and Herba Leonuri (15 g) to eliminate blood stasis and arrest
bleeding. For cases with amenorrhea after bleeding, add Radix Achyranthis
Bidentatae (10 g) and Rhizoma Zedoariae (10 g) to promote menstruation. For
cases with distending pain over the lower abdomen due to stagnation of qi and
blood, add Faeces Trogopterori (10 g), Pollen Typhae (wrapped in cloth, 10 g)
and Rhizoma Cyperi (10 g) to regulate qi and blood circulation, eliminate blood
stasis and stop pain.
(e) Dampness-heat syndrome
Manifestations: Continuous dripping bleeding with dark-purplish odorous
discharge containing clots, distending pain and tenderness over the lower
abdomen, fever, fatigue, heavy feeling in the extremities, thirst but without
desire for drink, red tongue with yellow, greasy coating and soft-floating and
rapid pulse.
Therapeutic principles: Clear away heat, eliminate dampness, and arrest
bleeding.
Prescription: The Modification of Three Wonder Drugs Decoction with
Sargentodoxae
Rhizoma Atractylodis 10 g
Caulis Sargentodoxae 15 g
Cortex Phellodendri 10 g
Herba seu Radix Cirsii Japonici 10 g
Herba Cephalanoploris 10 g
Herba Agrimoniae 15 g
Herba Patriniae 15 g
Semen Coicis 15 g
Herba Leonuri 15 g
Herba Verbenae 15 g
Rhizoma Cyperi Praeparata 10 g
Rhizoma Paridis 15 g
Remarks: For cases with heat as the predominant syndrome, use the Decoction of
Lonicerae, Forsythiae and Sargentodoxae for Removing Toxic Materials
Flos Lonicerae 15 g
Fructus Forsythiae 15 g
Caulis Sargentodoxae 15 g
Herba Patriniae 15 g
Semen Coicis 15 g
Cortex Moutan Radicis 10 g
Fructus Gardeniae 10 g
Radix Paeoniae Rubra 10 g
Semen Persicae 10 g
Rhizoma Corydalis 10 g
Fructus Toosendan 12 g
Olibanum 10 g
Myrrha 10 g
For cases with sudden profuse bleeding, fever, thirst, yellow, greasy tongue
coating and bounding, large pulse, add the following drugs to the above
decoction: Rhizoma Paridis (15 g), Rhizoma Dryopteris Crassirhizomae (10 g),
Flos Chrysanthemi Indici (10 g), Herba Hedyotis Diffusae (15 g), Herba
Artemisiae Annuae (10 g), Herba Agrimoniae (15 g) and Radix Rubiae (12 g), and
omit Coicis and Corydalis to clear away heat, cool the blood and stop bleeding.
Copyright 1995 Hopkins Technology |