Points - Recent Research
Gut Microbiota was Modulated by Moxibustion Stimulation in Rats with Irritable Bowel Syndrome
Effectiveness of Auricular Acupuncture in the Treatment of Cancer Pain
The Effects of Bu Yang Huan Wu Tang on Post-Stroke Epilepsy

Gut Microbiota was Modulated by Moxibustion Stimulation in Rats with Irritable Bowel Syndrome

Wang X#1,2, et al.

Background: The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of moxibustion in IBS treatment remains unknown.
Methods: An IBS rat model was established by colorectal distention (CRD) stimulus and mustard oil clyster. Sixty-five male rats were randomly divided into six groups: normal, IBS model, moxibustion, electroacupuncture (EA), Bifid-triple Viable Capsule (BTVC) and Pinaverium Bromide (PB) groups. The moxibustion group was treated with mild moxibustion at the bilateral Tianshu (ST25) and Shangjuxu (ST37) for 10 min/day for 7 days, the EA group was given EA at ST25 and ST37 once daily for 7 days, while the BTVC group and PB groups received Bifid-triple Viable Capsule and Pinaverium Bromide solution (at the proportion of 1:0.018) respectively by gavage once daily for 7 days. After the treatment, abdominal withdrawal reflex (AWR) scores were determined based on CRD stimulus, gut microbiota profiling was conducted by 16S rRNA high-throughput sequencing.
Results: Irritable bowel syndrome model rats had significantly increased AWR scores at all intensities (20, 40, 60 and 80 mmHg) compared with the normal group. Moxibustion treatment significantly reduced AWR scores compared with the IBS model group at all intensities. Across all groups the most abundant phyla were Bacteroidetes and Firmicutes followed by Proteobacteria and Candidatus Saccharibacteria. At genus level IBS model rats had a higher abundance of Prevotella, Bacteroides and Clostridium XI and a lower abundance of Lactobacillus and Clostridium XIVa compared with normal rats. These changes in microbiota profiles could however be reversed by moxibustion treatment. Alpha diversity was decreased in IBS model rats compared with normal rats, yet significantly increased in moxibustion- and PB-treated rats compared with IBS rats.
Conclusion: Our findings suggest that moxibustion treats IBS by modulating the gut microbiota.

Chin Med. 2018 Dec 18;13:63. doi: 10.1186/s13020-018-0220-y. eCollection 2018.

Source: PubMed

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Effectiveness of Auricular Acupuncture in the Treatment of Cancer Pain

Ruela LO1, et al.

OBJECTIVE: To evaluate the effectiveness of auricular acupuncture in the pain of cancer patients receiving chemotherapy and to verify if there were alterations in the use of analgesics after the application of this intervention.
METHOD:Randomized controlled trial with cancer patients with complaints of pain greater than or equal to four in the Numerical Pain Scale. Two parallel groups were created, an Experimental group, which received auricular acupuncture at energy balance points and at points indicated for the treatment of pain, and a Placebo group, in which fixed placebo points were used. Both groups received the application of semipermanent needles in eight sessions.
RESULTS: 31 cancer patients participated in the study. After the eight auricular acupuncture sessions, there was a significant difference between the groups regarding the reduction of pain intensity (p < 0.001) and of the use of medications (p < 0.05).
CONCLUSION:Auricular acupuncture was effective in reducing the pain of patients receiving chemotherapy. Brazilian Registry of Clinical Trials: RBR-6k3rqh.

Rev Esc Enferm USP. 2018 Dec 13;52:e03402. doi: 10.1590/S1980-220X2017040503402.

Source: PubMed

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The Effects of Bu Yang Huan Wu Tang on Post-Stroke Epilepsy

Weng SW1, et al.

Objective: To compare the long-term risk of epilepsy in stroke patients who use Bu Yang Huan Wu Tang (BYHWT) and those who do not.
Methods: In the Taiwanese national insurance claims data, we identified newly diagnosed stroke patients receiving inpatient care in the years 2000-2004. Using propensity score-matched pairs to balance the baseline characteristics, we selected eligible stroke patients who did (n=8,971) and did not (n=8,971) receive BYHWT. These two groups were followed up until the end of 2009 to track the occurrence of epilepsy. We used Cox proportional hazard models to calculate the adjusted HRs and 95% CIs for post-stroke epilepsy during the follow-up period according to BYHWT use.
Results: Compared with the control group, stroke patients with BYHWT had a reduced risk of epilepsy during the 5-9 years of the follow-up period (HR 0.69, 95% CI 0.61-0.77). The association between BYHWT and reduced post-stroke epilepsy was significant in various subgroups of stroke patients. There was a dose-dependent decrease in the frequency of epilepsy with increasing quantities of BYHWT use from 1 package (HR 0.77, 95% CI 0.66-0.90) to ≥6 packages (HR 0.52, 95% CI 0.42-0.65).
Conclusion: Stroke patients who received BYHWT therapy had a reduced long-term risk of epilepsy, and the beneficial effect could be observed in various subgroups. However, future clinical trials will be necessary to corroborate the present findings and identify the biochemical mechanism involved.

Clin Epidemiol. 2018 Dec 10;10:1839-1850. doi: 10.2147/CLEP.S175677. eCollection 2018.

Source: PubMed

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