Is Acupuncture Beneficial in Depression?
Wang H, et al. Department of Pharmacology and
Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University
School of Medicine, China.
BACKGROUND: Depression is one of the most common mental health disorders.
Acupuncture is a popular complementary and alternative medicine intervention
suggested in the treatment of depression, but its effectiveness is uncertain.
This updated meta-analysis was conducted to more precisely assess the beneficial
effect of acupuncture in depression therapy. METHODS: The following databases
were searched: MEDLINE, EMBASE, BIOSIS, Cochrane Central Register of Controlled
Trials, and Chinese Scientific Journal Database. The following terms were used:
acupuncture, acupressure, depression, depressive disorder, clinical trial, and
randomized controlled trial. RESULTS: Eight small-randomized controlled trials
comparing 477 subjects were included in the meta-analysis. Our results confirmed
that acupuncture could significantly reduce the severity of depression, which
was indicated by decreased scores of Hamilton rating scale for depression (HAMD)
or Beck Depression Inventory (BDI). The pooled standardized mean difference of
the 'Improvement of depression' was -0.65 (95% CI -1.18, -0.11; P=0.02) by
random effect model. However, no significant effect of active acupuncture was
found on the response rate (RR 1.32, 95% CI 0.83 to 2.10; P=0.25) and remission
rate (RR 1.30, 95% CI 0.57 to 2.95; P=0.53). CONCLUSION: Although this
meta-analysis might be discounted due to the low quality of individual trials,
it supported that acupuncture was an effective treatment that could
significantly reduce the severity of disease in the patients with depression.
More full-scale randomized clinical trials with reliable designs are recommended
to further warrant the effectiveness of acupuncture.
J Affect Disord. 2008 Jun 10
The Effect of Acupuncture at PC-6 on the Electroencephalogram
Kim MS, et al. Department of Electrical and
Electronic Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka,
Tempaku-cho, Toyohashi, Aichi, Japan 441-858, Japan. email@example.com.
The present study aims to examine the effect of acupuncture stimulation of an
acupuncture point (PC-6) and nonacupuncture point on electroencephalograms
(EEGs) and electrocardiograms (ECGs). We used EEG in 10 healthy subjects to
investigate cortical activation during stimulation of acupuncture points (neiguan:
PC-6) and nonacupuncture points. Our most interesting finding was the marked
differences of amplitude of EEG power between acupuncture points and
nonacupuncture points stimulation. Wavelet transform was used as the EEG signal
processing method, because it has advantages in a time domain and frequency
domain characteristics analysis. EEGs were collected from 16 channels, and the
alpha-wave (8-13 Hz), beta-wave (13-30 Hz), theta-wave (4-8 Hz) and delta-wave
(0.5-4 Hz) were used as standards for frequency bands. According to the
experiment results, EEG signals increased considerably after acupuncture
stimulation; in each frequency band, the average amplitude was higher after
acupuncture stimulation; ECG heart rates were faster by at least 10% after
acupuncture stimulation. Consequently, it will be possible to verify the
function of acupuncture stimulation on neiguan (acupuncture points; PC-6) more
Am J Chin Med. 2008;36(3):481-91
Effect of Tian Ma Gou Teng Decoction with Subtractive
Ingredients and its Active Constituents on Memory Acquisition
Ho SC, et al. Chinese Herbal Medicine Division,
Development Center for Biotechnology, Taipei, Taiwan. firstname.lastname@example.org.
Accumulating evidence indicates that the high blood pressure (BP) is a potent
risk factor for dementia in the elderly. In line with this theory, we had found
the mixture of Chinese herbs (TGD) which were traditionally used to treat
hypertension, could enhance the cognitive function. The aim of this study was to
decrease the number of herbs used from 11 (TGD) to 4 herbs (TGDS) and further to
search the active constituents. After administering a dose of 10 g/kg of TGDS0
to ICR mice, no cholinergic symptoms of lacrimation, salivation, emesis,
eyeclosure, increased respiration and fibrillation were observed. All the mice
survived without any deaths after 24 hours and 7 days. No changes were observed
in control and experimental groups on locomotor activity (no stimulant or
sedative effects). It was also revealed that TGDS could prolong the step-through
latency at the dose of 1.0 and 2.5 g/kg on passive avoidance tasks in mice. This
result was the same as the previous study. The active constituents which
enhanced the memory acquisition were discovered in the butanol layer and ethyl
acetate layer after the extraction.
Am J Chin Med. 2008;36(3):593-602