Remote Effect of Lower Limb Acupuncture on Latent Myofascial Trigger Point of Upper Trapezius Muscle
Chen KH, et al. Department of Physical Medical and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, Chiayi County 613,
Taiwan ; School of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Objectives. To demonstrate the use of acupuncture in the lower limbs to treat myofascial pain of the upper trapezius muscles via a remote effect. Methods. Five adults with latent myofascial trigger points (MTrPs) of bilateral upper trapezius muscles received acupuncture at Weizhong (UB40) and Yanglingquan (GB34) points in the lower limbs. Modified acupuncture was applied at these points on a randomly selected ipsilateral lower limb (experimental side) versus sham needling on the contralateral
lower limb (control side) in each subject. Each subject received two treatments within a one-week
interval. To evaluate the remote effect of acupuncture, the range of motion (ROM) upon bending the
contralateral side of the cervical spine was assessed before and after each treatment. Results. There was
significant improvement in cervical ROM after the second treatment (P = 0.03) in the experimental group,
and the increased ROM on the modified acupuncture side was greater compared to the sham needling side
(P = 0.036). Conclusions. A remote effect of acupuncture was demonstrated in this pilot study. Using
modified acupuncture needling at remote acupuncture points in the ipsilateral lower limb, our treatments
released tightness due to latent MTrPs of the upper trapezius muscle.
Evid Based Complement Alternat Med.2013;2013:287184. doi: 10.1155/2013/287184. Epub 2013 Apr 28.
Antidepressant-Like Effect of Ethanol Extract from Zuojin Pill,
Containing Two Herbal Drugs of Rhizoma Coptidis and Fructus Evodiae
Wang QS, et al. Research Center of Traditional Chinese Medicine, Tianjin University
of Traditional Chinese Medicine, No. 88 YuQuan Road, Nankai District, Tianjin 300193, PR China; Tianjin
State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine,
Tianjin 300193, PR China.
Zuojin Pill (ZJP), a traditional Chinese medicinal decoction, contains two herbal drugs: Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. in the ratio of 6:1 (w/w). Previous pharmacological studies have shown that two herbs in ZJP have the antagonistic effects on catecholamine secretion in bovine adrenal medullary cells. Furthermore, the alkaloids from the two herbs in ZJP may provide a protective effect for depression in individuals with a low expressing 5-HTT allele by increasing receptor concentration in serotonergic neurons. However, antidepressant effect has not been reported before and has not been fully clarified. AIM OF THE STUDY: The present study aimed to investigate the antidepressant potential of ethanol extract from ZJP and its monoaminergic mechanism in mice. MATERIALS AND METHODS: Seven alkaloids were determined from the ethanol extract of ZJP using High Performance Liquid Chromatography (HPLC) with the gradient mobile phase. The ethanol extract from ZJP was used to evaluate the antidepressant potential in mice. Mouse models of depression including the tail suspension test (TST) and the forced swim test (FST) were used to evaluate the effects of the ethanol extract from ZJP. A possible mechanism was explored in the tests of antagonism of reserpine-induced ptosis and hypothermia, and 5-HTP induced head twitch response in mice. The contents of monoamine neurotransmitters including norepinephrine (NE), serotonin (5-hydroxytryptamine or 5-HT) in hippocampus of mice and NE, 5-HT, dopamine (DA) in striatum of mice were determined by HPLC system with Electrochemical Detector (ECD). RESULTS: The results showed that intragastric administration of the ethanol extract from ZJP (5, 10, 20mg/kg) or fluoxetine (7.5mg/kg) significantly reduced the duration of immobility in TST and FST. However, the effect was not dose-dependent. Ethanol extract from ZJP (5, 10, 20mg/kg) also increased the accumulative
number of the 5-HTP-induced head twitch response in mice. The mice were treated with the ethanol extract
from ZJP (5, 10, 20mg/kg) or fluoxetine (7.5mg/kg), which could antagonize reserpine-induced ptosis and
hypothermia, moreover, both of them could elevate the contents of NE, 5-HT in hippocampus as well as NE,
5-HT, DA in striatum significantly. CONCLUSION: These results indicate that the ethanol extract from ZJP
produced antidepressant-like effect and the possible mechanism, at least in part, is via the central
monoaminergic neurotransmitter system and 5-HT plays a major role.
J Ethnopharmacol.2013 May 20. pii: S0378-8741(13)00347-4. doi: 10.1016/j.jep.2013.05.011. [Epub ahead of print]
Acupuncture for Treatment of Arthralgia Secondary to Aromatase Inhibitor Therapy in Women with Early Breast Cancer
Oh B, et al. Sydney Medical School, University of Sydney, , Sydney, New South Wales, Australia.
BACKGROUND: Aromatase inhibitors (AIs) are recommended as adjuvant hormone treatment for postmenopausal women with early breast cancer. A substantial proportion of women taking AIs experience joint pain and stiffness. Studies have suggested that acupuncture may be effective in treating joint pain. OBJECTIVE: A pilot study was conducted to evaluate the feasibility, safety and efficacy of using acupuncture to treat AI-induced arthralgia. METHODS: A total of 32 patients were randomised to receive either sham or real electroacupuncture (EA) twice weekly for 6 weeks. Outcomes of joint pain, stiffness and physical function were measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), overall pain severity and interference with the BPI-SF and quality of life (QOL) with the Functional Assessment of Cancer Therapy-General (FACT-G) instrument. Hand strength was assessed by a grip test, and a serum marker of inflammation (C reactive protein (CRP)) was also measured. All assessments were performed at baseline, 6 weeks and 12 weeks, except for blood samples at baseline and 6 weeks only. RESULTS: No serious adverse events were reported during or after acupuncture treatments.
There were no significant differences in outcome measures. However, positive trends were observed in
stiffness and physical function at week 12 in favour of real EA. CONCLUSIONS: Findings suggest that
acupuncture is feasible and safe in patients with breast cancer with joint pain caused by AI. A larger
study with adequately powered to confirm these results and detect clinically relevant effects
Acupunct Med. 2013 May 30. [Epub ahead of print]