Interaction of Salvianolic Acids and Notoginsengnosides in
Inhibition of ADP-Induced Platelet Aggregation
Yao Y, et al. Shanghai Research Center for
Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia
Medica, Chinese Academy of Sciences, Shanghai, China.
Salvia miltiorrhiza and Panax notoginseng were both considered to be
beneficial to cardiovascular diseases in traditional Chinese medicine
and often used in combination. To examine the possible interaction
between them, the effects of the active fractions of these two herbs,
salvianolic acids (SA) and notoginsengnosides (NG), on platelet
aggregation were checked respectively or in combination in vitro and
in vivo. Both the platelet aggregation of platelet rich plasma (PRP)
and washed platelet after ADP induction were checked. In vitro study
showed that both SA and NG had an inhibitory effect on platelet
aggregation. However, there is no synergistic effect of the
combination of SA and NG in vitro. In vivo study showed that i.g. 550
mg/kg/day SA or NG for 5 days could significantly inhibit ADP-induced
platelet aggregation of PRP. Moreover, combination of SA and NG at a
ratio of 5:1 had a synergistic effect on platelet aggregation of PRP.
The mechanism for the synergism of SA and NG in vivo was not clear.
High performance liquid chromatography analysis of the plasma of rats
received SA, NG or combination of SA and NG showed that
co-administration of NG caused change in the plasma distribution
profile of SA. The influence of combination on the absorption and/or
metabolism of SA may be one of the reasons for the synergism of SA and
NG in vivo.
Am J Chin Med. 2008;36(2):313-28.
Effect of Earlobe-Bleeding Plus Body Acupuncture in 85 cases
of Common Acne
Liu Z. Acupuncture Institute, China Academy of
Chinese Medical Sciences, Beijing 100700, China.
OBJECTIVE: To observe the clinical effect of earlobe-bleeding plus body
acupuncture for common acne. METHODS: The earlobe-bleeding plus local and body
acupuncture based on syndrome differentiation was adopted for 85 cases of common
acne. RESULTS: Of the 85 cases treated, 61 were cured, 12 markedly effective, 9
improved, and 3 failed. The total effective rate was 96.47%. CONCLUSIONS: The
therapy can treat both the Biao-symptom and Ben-root of common acne, short in
course and effective in result.
J Tradit Chin Med. 2008 Mar;28(1):18-20.
Extraarticular Gold Bead Implantation for Treatment of Knee
Nejrup K, et al. General Practice, Holte,
The primary objective of this double-blind, randomised, controlled trial was to
determine if implanting gold beads at five acupuncture points around the knee
joint improves 1-year outcomes for patients with osteoarthritis (OA) of the
knee. Participants were 43 adults aged 18-80 years with pain and stiffness from
non-specific OA of the knee for over a year. The intervention was blinded
implantation of gold beads at five acupuncture points around the affected knee
through a hypodermic needle, or needle insertion alone. Primary outcome measures
were knee pain, stiffness and function assessed by the patient at 0, 1, 3, 6, 9
and 12 months and knee score and knee function assessed by an orthopaedic
surgeon at 0, 6 and 12 months. Within the first month, three patients dropped
out. The remaining 21/19 patients in the intervention/control groups generally
improved, but there was no statistically significant difference between the
groups. The improvement was shown in the patients' self-assessment scores that
decreased from randomisation until 1 year later (intervention/control group,
medians): pain -1.92/-2.18 (P = 0.95, F test, general linear mixed model);
stiffness -0.93/-0.43 (P = 0.11); function -7.23/-3.36 (P = 0.63). The surgeon's
scores also generally improved, i.e. increased: knee score +16.4/+8.2 (P =
0.65); knee function +10.5/+5.8 (P = 0.79). In the protocol-based subgroup
analysis, the 15 intervention patients of the 32 patients who had a positive
response to the initial conventional acupuncture had greater relative
improvements in self-assessed outcomes. The treatment was well tolerated. This
1-year pilot study indicates that extraarticular gold bead implantation is a
promising treatment modality for patients with OA of the knee. The new treatment
should be tested in a larger trial including only patients who respond
positively to initial conventional acupuncture.
Clin Rheumatol. 2008 May 24.