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Home > Newsletters > May 2009 > Recent Research

Points - Recent Research

Comparison of the Effectiveness of Six and Two Acupuncture Point Regimens in Osteoarthritis of the Knee

Acupuncture in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

In Vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis Chinensis (Huang Lian) and Evodia Rutaecarpa (Wu Zhu Yu)


Comparison of the Effectiveness of Six and Two Acupuncture Point regimens in Osteoarthritis of the Knee

Taechaarpornkul W, et al. Sirindhorn National Medical Rehabilitation Center, 88/26 Soi Bamrasnaradura, Tiwanon Road, Nonthaburi 11000, Thailand; wiratt@health.moph.go.th.

BACKGROUND: Although substantial data have supported the effectiveness of acupuncture for treating knee osteoarthritis (OA), the number of points used has varied. The objective of this study was to compare the effectiveness of six and two acupuncture points in the treatment of knee OA. METHODS: A randomised trial of knee OA patients was conducted. Patients were randomly allocated into two groups of 35. The "six point group" received treatment at six acupuncture points, ST35, EX-LE4 (Neixiyan), ST36, SP9, SP10 and ST34, while the "two point group" received treatment at just the first pair of points, ST35 and EX-LE4. Both groups received twice weekly electroacupuncture on 10 occasions. Electrical stimulation was carried out at low-frequency of 3 Hz to all points, with the intensity as high as tolerable. Both groups were allowed to take a 200 mg celecoxib capsule per day for intolerable pain. Patients were assessed at baseline, week 5, week 9 and week 13, using a Thai language version of the Western Ontario and McMaster Osteoarthritis Index (WOMAC). Global assessment of change after 10 treatments was also recorded. RESULTS: Acupuncture at both six and two acupuncture points was associated with significant improvement. Mean total WOMAC score at weeks 5 and 13 of patients in both groups showed no significant difference statistically (p = 0.75 and p = 0.51). Moreover, the number of celecoxib capsules taken, global assessment of global change and body weight change of both groups also showed no statistical difference. CONCLUSION: This evidence suggests that electroacupuncture to two local points may be sufficient to treat knee OA, but in view of some limitations to this study further research is necessary before this can be stated conclusively.

Acupunct Med. 2009 Mar;27(1):3-8. Links

Source: PubMed

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Acupuncture in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Whale CA, et al. John Eastwood Hospice, Mansfield Road, Sutton-in-Ashfield, Nottinghamshire NG17 4HJ; claudiahallam@doctors.org.uk.

BACKGROUND: Exacerbation of chronic obstructive pulmonary disease (COPD) is a common reason for hospital admission, and adjunctive non-pharmacological treatments would be welcomed. A pilot study was undertaken to assess the feasibility of conducting a study of acupuncture during an acute exacerbation of COPD. We also examined the credibility of a sham device in this setting and assessed the effect of acupuncture on breathlessness and Anxiety. METHODS: A prospective, randomised, patient- and assessor-blinded, sham controlled study was conducted on three consecutive days in a district general hospital. Credibility of both acupuncture and the Park sham device were assessed using the Borkovec and Nau questionnaire. Dyspnoea was measured on the modified Borg score and a 10 cm visual analogue scale, while Anxiety was measured on a 10 cm visual analogue scale. RESULTS: 11 patients were recruited and nine completed the study. There were no adverse events with either intervention. Acupuncture was well tolerated and credibility scores were similar before and after real and sham acupuncture. Symptoms improved after both treatments, with no significant difference between groups. CONCLUSION: In this pilot study acupuncture was well tolerated by subjects experiencing an acute exacerbation of COPD. Acupuncture treatment and the Park sham device were both credible. Although recruitment was slow, a further trial with a larger sample size is feasible and recommended.

Acupunct Med. 2009 Mar;27(1):13-5.

Source: PubMed

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In Vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis Chinensis (Huang Lian) and Evodia Rutaecarpa (Wu Zhu Yu)

Wang XN, et al. College of Pharmacy, Dalian Medical University, Dalian, P. R. China.

The aim of the present paper was to investigate the synergistic effect and mechanism of anticancer activity of ZUOJINWAN ( ZJW) comprising COPTIS CHINENSIS Franch ( HL) and EVODIA RUTAECARPA (Juss.) Benth ( WZY) at a ratio of 6 : 1 (w/w). IN VIVO anticancer activity testing was carried out by inhibiting the growth of S180 tumor. Tumor growth inhibition, spleen index, lymphocyte proliferation, apoptosis, tumor necrosis factor-alpha (TNF-alpha) level, activities of serum tumor markers (TMs), increase in life span (ILS), histopathology and gene expression were tested. The results indicated that ZJW could significantly induce apoptosis of cancer cells. The inhibition ratio, ILS and TNF-alpha levels of mice treated with ZJW were 50.54 %, 64.91 % and 1.04 ng/mL, respectively, much higher than HL and WZY when singly used. Furthermore, the activities of acid phosphatase and alkaline phosphatase were significantly increased and the activities of creatine kinase, aldolase and lactate dehydrogenase were reduced in serum, and the expressions of Bax and wild-type p53 proteins were much higher for the mice treated by ZJW compared with HL and WZY single-treatment groups. A clear synergistic effect on the anticancer activity was observed with ZJW, and the mechanism of antitumor growth may be due to an effect on gene expression and activities of tumor markers in serum.

Planta Med. 2009 Apr 6.

Source: PubMed

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