Points - Recent Research
Electroacupuncture for Postmenopausal Women with Stress Urinary Incontinence
Postoperative Analgesia by Adding Acupuncture to Conventional Therapy
Guzhi Zengsheng Zhitongwan, a Traditional Chinese Medicinal Formulation, Stimulates Chondrocyte Proliferation through Control of Multiple Genes Involved in Chondrocyte Proliferation and Differentiation

Electroacupuncture for Postmenopausal Women with Stress Urinary Incontinence

Wang W1, et al.

PURPOSE: The efficacy and safety of electroacupuncture was compared to those of sham electroacupuncture for the treatment of postmenopausal women with stress urinary incontinence (SUI).
METHODS: This study was a secondary analysis of a multicenter, randomized controlled trial that recruited 504 women with SUI and randomized 349 postmenopausal women to receive 18 treatment sessions of electroacupuncture or sham electroacupuncture over 6 weeks, with a 24-week follow-up assessment. Treatment response was defined as a 50% or greater reduction in urine leakage, as measured by a 1-h pad test at week 6.
RESULTS: Of the 349 randomized women, 332 completed the study. The response rate was 61.0% in the electroacupuncture group compared to 18.9% in the sham electroacupuncture group (difference 42.5%; 95% confidence interval, 33.3-51.7; p < 0.001). After 6 weeks of treatment, the mean 72-h urinary incontinence episode frequency, proportion of participants with at least a 50% decrease in mean 72-h incontinence episode frequency, participant-reported SUI severity, International Consultation on Incontinence Questionnaire-Short Form scores, and participants' self-evaluation of therapeutic effects improved in both groups, with significant between-group differences. Treatment-related adverse events occurred in 2.1% of women during the 6-week treatment.
CONCLUSION: Electroacupuncture may effectively and safely relieve urinary incontinence symptoms and improve quality of life in postmenopausal women with SUI.

World J Urol. 2018 Oct 13. doi: 10.1007/s00345-018-2521-2. [Epub ahead of print]

Source: PubMed

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Postoperative Analgesia by Adding Acupuncture to Conventional Therapy

Levy I1, et al.

Background Postoperative pain is common in patients hospitalized in surgical departments, yet it is currently not sufficiently controlled by analgesics. Acupuncture, a complementary medical practice, has been evaluated for its benefits in postoperative pain with heterogeneous results. We tested the feasibility of a controlled study comparing the postoperative analgesic effect of acupuncture together with standard-of-care to standard-of-care only. Methods In this pilot non-randomized controlled study conducted at a tertiary medical center in Israel, patients received either acupuncture with standard-of-care pain treatment (acupuncture group) or standard-of-care treatment only (control group) following surgery. Visual Analogue Scale (VAS) ratings for pain level at rest and in motion were evaluated both at recruitment and two hours after treatment. Acupuncture-related side effects were reported as well. Results We recruited 425 patients; 336 were assigned to the acupuncture group and 89 to the control group. The acupuncture group exhibited a decrease of at least 40% in average level of pain both at rest (1.82.4, p<0.0001) and in motion (2.12.8, p<0.0001) following acupuncture, whereas the control group exhibited no significant decrease (p=0.92 at rest, p=0.98 in motion). Acupuncture's analgesic effect was even more prominent in reducing moderate to severe pain at baseline (VAS ≥4), with a decrease of 49% and 45% of pain level at rest and in motion respectively (p<0.001), compared with no significant amelioration in the control group (p=0.20 at rest, p=0.12 in motion). No major side effects were reported. Conclusion Integrating acupuncture with standard care may improve pain control in the postoperative setting.

J Complement Integr Med. 2018 Oct 12. pii: /j/jcim.ahead-of-print/jcim-2018-0028/jcim-2018-0028.xml. doi: 10.1515/jcim-2018-0028. [Epub ahead of print]

Source: PubMed

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Guzhi Zengsheng Zhitongwan, a Traditional Chinese Medicinal Formulation, Stimulates Chondrocyte Proliferation through Control of Multiple Genes Involved in Chondrocyte Proliferation and Differentiation

Yao B1, et al.

Chinese materia medica (CMM) are essential components of traditional Chinese medicine, and Chinese medicinal formulas consisting of 2 or more types of CMM are widely used. These formulations have played a pivotal role in health protection and disease control for thousands of years. Guzhi Zengsheng Zhitongwan (GZZSZTW), which represents one of the Chinese medicinal formulations, has been used for several decades to treat joint diseases. However, the exact molecular mechanism underlying its efficacy in treating osteoarthritis remains to be elucidated. In the present study, we investigated the effects of GZZSZTW on primary chondrocytes. We demonstrated that GZZSZTW significantly promoted chondrocyte viability, maintained chondrocytes in a continuous proliferative state, and prevented their further differentiation. These effects were achieved by the synergistic interactions of various herbs and their active components in GZZSZTW through an increase in the expression levels of functional genes participating in chondrocyte commitment and proliferation and a decrease in the expression levels of genes involved in chondrocyte differentiation. GZZSZTW treatment also decreased the expression levels of genes that inhibited chondrocyte proliferation. Thus, this study has greatly deepened the current knowledge about the molecular effects of GZZSZTW on chondrocytes. It has also shed new light on possible strategies to further prevent and treat cartilage-related diseases by using traditional Chinese medicinal formulations.

Evid Based Complement Alternat Med.2018 Sep 12;2018:7265939. doi: 10.1155/2018/7265939. eCollection 2018.

Source: PubMed

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