Effects of BL 23 (Shenshu) Acupuncture on Serum Cytokine Levels in Healthy Adults
Eiko Murakami, et al.
Abstract
The purpose of this study was to evaluate the safety and efficacy of BL 23 (Shenshu) acupuncture on serum cytokine levels. Sixteen healthy
adults were randomized into the BL 23 acupuncture group or pseudo-acupuncture group and changes of serum cytokines were analyzed. The changes
in IL-13, TNF-?, and GM-CSF levels were different between the BL 23 acupuncture group and pseudo-acupuncture group (P < 0.05). No adverse events
associated with acupuncture were observed. In conclusion, BL 23 acupuncture can suppress immune responses via decreases in TNF-?
and suppression of increases in IL-13 and GM-CSF. This study elucidated some of the mechanisms of the acupuncture effect.
Journal of Neuroimmunology Volume 382, 15 September 2023, 578165
Source: ScienceDirect
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Efficacy and Safety of Acupuncture for Pregnancy-Related Low Back Pain
Rong Li, et al.
Abstract
Background
Pregnancy-related low back pain (PLBP) is a common musculoskeletal disorder, affecting people's physical and psychological health. Acupuncture
is widely used in clinical practice as a treatment for PLBP. This study aimed to evaluate the efficacy and safety of acupuncture or acupuncture
combined with other treatments for PLBP patients.
Methods
The Cochrane Library, PubMed, EMBASE, Web of Science, the Chinese Biological Medicine Database, China National Knowledge Infrastructure,
WanFang Database, and VIP information database were searched from inception to January 31, 2022. Randomized controlled trials (RCTs) were
eligible, without blinding and language restriction. Cochrane's risk of bias tool was used to assess the methodological quality. Meta-analysis
was performed using RevMan 5.3.
Results
Twelve randomized controlled trials involving 1302 patients were included. The results showed that compared to the control group, the VAS score
was significantly decreased after acupuncture treatment. In addition, no significant difference was found in the preterm delivery rate
(RR = 0.38, 95%CI: 0.24 to 0.61, P = 0.97) after acupuncture treatment. Compared with other therapies, acupuncture or acupuncture plus
other therapies revealed a significant increase in the effective rate (OR: 6.92, 95%CI: 2.44 to 19.67, I2 = 0%). No serious adverse events
owing to acupuncture were reported.
Conclusion
Acupuncture or acupuncture combined with other interventions was a safe and effective therapy for treating PLBP. However, the methodological
quality of the RCTs was low. More rigorous and well-designed trials should be conducted.
Heliyon Volume 9, Issue 8, August 2023, e18439
Source: ScienceDirect
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Evaluation of the Efficacy and Safety of Suxiao Jiuxin Pill in the Treatment of Stable Angina
Yuan-long Sun, et al.
Abstract
Ethnopharmacological relevance
The Suxiao Jiuxin Pill (SJP) has been used for treating chronic stable angina (SA) for more than 40 years in China. SJP is composed of two
Chinese herbs and has the effect of activating blood and promoting qi, according to traditional Chinese medicine (TCM) theory.
Aim of the study
The study aims to determine the effects of adjunct SJP on conventional therapy in patients with SA which provides a complementary choice and
its evidence for clinical medication for treating SA.
Materials and methods
Participants with SA were recruited and randomized 1:1 to either the SJP group or the control group for 24 weeks. Both groups received
conventional treatment according to local tertiary hospital protocols, and the participants received additional SJP (composed of Ligusticum
wallichii and Borneol) or placebo in treatment and control groups respectively. The primary outcome was the curative efficacy rate at week 4.
Secondary outcomes are the curative efficacy rate, the total score of angina pectoris symptoms, CCS Angina Classification improvement,
Seattle Angina Questionnaire (SAQ) score, TCM syndrome scores (TCMSS), and the curative efficacy rate of TCMSS. Adverse events and adverse
drug reactions were observed and recorded for safety analysis.
Results
A total of 324 participants with SA from 13 hospitals in China were enrolled in this trial. Compared with the control group, the curative
efficacy rate of SA, the curative efficacy rate of TCMSS significantly increased, and the total score of angina pectoris symptoms and TCMSS
significantly reduced in the SJP group at week 4, 12, and 24, accompanied by the statistically significant improvement in the curative efficacy
rate based on CCS grade reduction (all P < 0.05). Furthermore, the SAQ score (physical limitation, angina stability, and treatment satisfaction)
was evaluated as the quality of life significantly improved after treatment (P < 0.05). The medication compliance, concomitant medication,
and rates of adverse events were similar between the two groups (P > 0.05).
Conclusion
The present prospective, multicenter, randomized, double-blind, placebo-controlled, clinical trial confirms that adjunct SJP to conventional
treatment increased the curative efficacy and life quality of SA patients with no significant adverse drug reactions during the clinical
application.
Journal of Ethnopharmacology Volume 318, Part A, 10 January 2024, 116959
Source: ScienceDirect
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